Nanotoxicity

Nanotoxicology refers to the study of the interactions of nanostructures with biological systems with an emphasis on identifying the relationship between the physical and chemical properties of nanostructures and induction of toxic biological responses. A complete understanding of the relationship between unique properties of nanostructures and in vivo and in vitro behaviors will provide a strong basis for assessing toxic responses. Studies in animal models will identify the organs of interest, in turn leading to identification of the best cell types for in vitro cytotoxicity studies to further enhance our understanding of how these cells molecularly respond to the nanostructures. Toxicologic tests and the resulting database would provide information for material safety data sheets for nanoparticles as well as a basis for risk assessment and management.

  • Oxidative stress
  • Cytotoxicity
  • Genotoxicity

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